取得学位・資格
MD, PhD
個人/所属ウェブページ
http://www.tm.nagasaki-u.ac.jp/hiraken/
ResearchGate/LinkedInアカウント
https://www.researchgate.net/profile/Kenji_Hirayama
他所属
Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University
経歴
- 2001-： Professor, NEKKEN, Nagasaki University
- 1995-2001：Professor, Saitama Medical University
- 1989-92: Research Fellow, Harvard School of Public Health
- 1985-89: Medical Institute of Bioregulation, Kyushu University
- 1981-85: PhD course, Human Genetics, Medical Research Institute, Tokyo Medical and Dental University
教育活動
Current roles: Course Director of Health Innovation, Responsible for Immunology and Biotechnology courses
Teaching experience: Course Director of Master of Tropical Medicine, Nagasaki University Graduate school of Biomedical Science. Medical Parasitology, Clinical Immunology, Tropical Infectious diseases, Tropical Public Health, Research Ethics, Vaccinology, Clinical Product Development
研究活動
Vaccine development for malaria, Dengue, and Chagas Disease using DNA or recombinant vaccine. (Hisamitsu, Pasteur Paris, European Vaccine Initiative)
Drug development for malaria and trypanosomiasis using compound designing or herbal medicine. (Astellas, National Institute of Advanced Industrial Science and Technology, Institute of Natural Medicine Toyama University, Thammasat University)
HLA regulated Immune responsiveness against malaria, dengue, Chagas and Schistosomiasis. (Tokyo Med Dent University, Research Institute of Tropical Medicine, Philippines, Pasteur Institute Ho Chi Minh, Kenya Medical Research Institute)
http://www.tm.nagasaki-u.ac.jp/hiraken/english/index.html
現在の主な研究活動地域
- France
- Germany
- UK
- Thailand
- Vietnam
- Myanmar
- Philippines
- Kenya
- Bolivia
- Paraguay
- DRCongo
最近の5つの出版物
- Nhi DM, Huy NT, Ohyama K, Kimura D, Lan NT, Uchida L, Thuong NV, Nhon CT, Phuc le H, Mai NT, Mizukami S, Bao LQ, Doan NN, Binh NV, Quang LC, Karbwang J, Yui K, Morita K, Huong VT, Hirayama K. A Proteomic Approach Identifies Candidate Early Biomarkers to Predict Severe Dengue in Children. PLoS Negl Trop Dis. 2016 Feb 19;10(2):e0004435. doi: 10.1371/journal.pntd.0004435. eCollection 2016 Feb.
- Tanigawa C, Fujii Y, Miura M, Nzou SM, Mwangi AW, Nagi S, Hamano S, Njenga SM, Mbanefo EC, Hirayama K, Mwau M, Kaneko S. Species-Specific Serological Detection for Schistosomiasis by Serine Protease Inhibitor (SERPIN) in Multiplex Assay. PLoS Negl Trop Dis. 2015 Aug 20;9(8):e0004021. doi: 10.1371/ journal. pntd.0004021. eCollection 2015 Aug.
- Mercado ES, Espino FE, Perez ML, Bilar JM, Bajaro JD, Huy NT, Baello BQ, Kikuchi M, Hirayama K. HLA-A*33:01 as protective allele for severe dengue in a population of Filipino children. PLoS One. 2015 Feb 6;10(2):e0115619. doi: 10.1371/journal.pone.0115619. eCollection 2015.
- Fujii Y, Kaneko S, Nzou SM, Mwau M, Njenga SM, Tanigawa C, Kimotho J, Mwangi AW, Kiche I, Matsumoto S, Niki M, Osada-Oka M, Ichinose Y, Inoue M, Itoh M, Tachibana H, Ishii K, Tsuboi T, Yoshida LM, Mondal D, Haque R, Hamano S, Changoma M, Hoshi T, Kamo K, Karama M, Miura M, Hirayama K. Serological surveillance development for tropical infectious diseases using simultaneous microsphere-based multiplex assays and finite mixture models. PLoS Negl Trop Dis. 2014 Jul 31;8(7):e3040. doi: 10.1371/journal.pntd.0003040. eCollection 2014.
- Cherif MS, Shuaibu MN, Kodama Y, Kurosaki T, Helegbe GK, Kikuchi M, Ichinose A, Yanagi T, Sasaki H, Yui K, Tien NH, Karbwang J, Hirayama K. Nanoparticle formulation enhanced protective immunity provoked by PYGPI8p-transamidase related protein (PyTAM) DNA vaccine in Plasmodium yoelii malaria model. Vaccine. 2014 Apr 7;32(17):1998-2006. doi: 10.1016/j.vaccine.2014.01.005. Epub 2014 Jan 15.
メッセージ
免疫遺伝学が専門ですが，現在主に興味を持っているのは，たくさんの人が罹患し高い死亡率をしめす熱帯感染症の予防や治療に直結するような研究です。具体的には，マラリアや住血吸虫症，デング出血熱など一つ間違えば非常に重症化する病気のメカニズムの解明と，これら３つの感染症の医薬品や予防ワクチンの開発をめざしています。ワクチンの開発など医薬品の開発はもともと医者を志したときからの夢ですが，なかなか基礎研究から製品開発へつなげることは一人の力では容易ではありません。研究所や大学，あるいは国全体，さらには国際ネットワークなどが力をあわせて取り組むべき事業であると思います。この10年ぐらい，そのような取り組みを種々のNPOや政府あるいは国際機関あるいは企業と連携して進めています。一緒に勉強しましょう。